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Malyari ya bang akit ning simpleng urine test ing early stage ning Alzheimer's disease, a magbukas dalan para kareng mass screening programs? Ing bayung Frontiers in Aging Neuroscience a pamagaral siguradung papakit na ini. Deng talapanaliksik sinubukan de ing maragul a grupu da reng pasyenti ning Alzheimer's a miyayaliwang severity ampo deng malusug a indibidwal na cognitively normal para abalu da ing pamiyaliwa da reng urine biomarkers.
Ikit da na ing formic acid keng ihi metung yang sensitibong marker ning subjective cognitive decline at malyari yang magpasyag keng mumunang yugtu ning sakit a Alzheimer. Deng kasalukuyan a paralan para abalu ing sakit a Alzheimer mamasa la, e kumbinyenti, ampo e la malyaring gamitan keng routine screening. Buri ng sabyan niti, keraklan kareng pasyenti mayayakit la mu nung masyadu neng malati para keng epektibung pamanulu. Makanyan man, ing e makalub, mura, at manyaman a urinalysis para keng formic acid malyari yang eksaktung buri da reng doktor para keng early screening.
"Ing sakit a alzheimer metung yang persistent at insidious chronic disease, buri ng sabyan malyari yang lumabung at manatili kilub ning dakal a banua bayu ya lumwal ing overt cognitive impairment," ngara reng talasulat. "Ing mumunang yugtu ning sakit malilyari ya bayu ing yugtu ning e malyaring ibalik a demensya, a metung a gintung bintana para king pamakialam at pamanulu. Inya, ing maragul a pamag-screen para king mumunang yugtu ning sakit a Alzheimer kareng matwa kailangan ya."
Kaya, nung importanti ing mabilis a pamag-interbensyun, bakit ala tamung routine screening programs para keng early stage Alzheimer's disease? Ing problema atyu ya keng paralan ning pamagsuri a gagamitan da reng doktor ngeni. Kayabe la kareti deng positron emission tomography ning utak, a mamasa at papalwal no reng pasyenti king radiation. Atin mu namang biomarker tests a malyaring makatuklas keng Alzheimer's, pero mangailangan lang invasive blood draws o lumbar punctures para mika cerebrospinal fluid, na malyaring ilako da reng pasyenti.
Makanyan man, deng urine tests ali la invasive ampo convenient la, inya masanting la para keng mass screening. Agyang deng talapanaliksik mekilala nala deng urine biomarkers para keng Alzheimer's disease, ala metung man ing makayagpang para abalu ing mumunang yugtu ning sakit, buri ng sabyan ing golden window para keng mumunang panulu manatili yang e malino.
Deng talapanaliksik keng gulut ning bayung pamagaral minunang megaral lang organic compound a ausan dang formaldehyde bilang urine biomarker para keng Alzheimer's disease. Makanyan man, atin pang lugal para keng pamagbayu keng mabilis a pamangilala keng sakit. Kening bayung pamagaral, tinuknang la keng formate, metung a formaldehyde metabolite, para akit nung mas masanting ya bilang biomarker.
Atin yang 574 a tau ing mekiabe keng pamagaral, at deng mekiabe metung la kareng cognitively normal a malusog a volunteers o atin lang miyayaliwang degree ning pamagprogresu ning sakit, manibat keng subjective cognitive decline angga na keng kumpletung sakit. Ding talapanaliksik sinuri de ing ihi ampo daya da reng partisipanti ampo ginawa lang psychological assessment.
Ing pamagaral ikit na ing urinary formic acid levels makabaldugan yang matas kareng eganaganang grupu ning Alzheimer's disease at makaugne ya keng cognitive decline kumpara kareng malusog a kontrol, kayabe na ing early subjective cognitive decline group. Iti magpasyag na ing formic acid malyari yang magsilbing sensitibong biomarker para kareng mumunang yugtu ning sakit a Alzheimer.
Ing makawili, inyang sinuri da reng talapanaliksik ing urine formate levels a kayabe da reng Alzheimer's blood biomarkers, ikit da na mas ustu lang abalu ing yugtu ning sakit a daralanan ning pasyenti. Makanyan man, kailangan ing karagdagang pamanyaliksik ba yang aintindian ing kaugnayan ning sakit a Alzheimer ampo ing formic acid.
"Ing formic acid keng ihi pepakit na ing masanting a sensitivity para keng early screening para keng Alzheimer's disease," ngara reng talasulat. "Ing urine biomarker testing para keng Alzheimer's disease manyaman ya at e ya gastus at dapat yang iyabe keng routine health screenings para kareng matwa."
Wang, Y. et al. (2022) Systematic review ning urinary formic acid bilang metung a bayung biomarker para keng Alzheimer's disease. Frontiers keng neurobiology ning pamagbayu. doi.org/10.3389/fnagi.2022.1046066.
Tags: aging, Alzheimer's disease, biomarkers, daya, utak, chronic, chronic diseases, compounds, dementia, diagnostics, doctors, formaldehyde, neurology, positron emission tomography, research, tomography, urinalysis
King Pittcon 2023 king Philadelphia, Pennsylvania, ininterbyu mi ya i Professor Joseph Wang, ing sinambut king Ralph N. Adams Prize king Analytical Chemistry ngening banua, tungkul king panga-versatility ning biosensor technology.
Kening interview ayni, pisabyan mi ing respiratory biopsy ampo nung makananu yang maging kapakibatan a kasangkapan para abalu ing biomarkers para keng early disease detection kayabe nang Mariana Leal, Team Leader keng Owlstone Medical.
Bilang dake ning kekaming SLAS US 2023 review, pag-usapan mi ing lab ning hinaharap at nung nanu ya itsura kayabe nang Luigi Da Via, GSK Test Development Team Lead.
Ing News-Medical.Net mamye yang serbisyung impormasyun medikal a makayagpang kareng terms and conditions. Pakibaluan mu na ing impormasyun medikal kening website ayni para suportan, at ali palitan, ing relasyun ning doktor/doktor ning pasyenti ampo ing payu medikal a malyari dang ibie.