Ing malagkit a kilwal a layer da reng fungi ampo bacteria, a ausan dang "extracellular matrix" o ECM, atin yang consistency ning jelly ampo gagawan neng protective layer ampo shell. Pero agpang keng bayung pamagaral keng journal iScience, a gewa ning University of Massachusetts Amherst kayabe ning Worcester Polytechnic Institute, ing ECM da reng mapilan a microorganisms gagawang gel nung atin mung oxalic acid o aliwang simple acid. Uling ing ECM atin yang importanting papil keng sabla manibat keng antibiotic resistance angga na kareng makabara a pipe ampo keng kontaminasyun da reng medical devices, ing pamangilala nung makananu lang manipulan deng microorganisms deng karelang sticky gel layers atin yang malawak a implikasyon keng aldo-aldo tamung pamibiebie.

"Parati kung interesadu kareng microbial ECMs," sinabi nang Barry Goodell, professor ning microbiology keng University of Massachusetts Amherst ampo senior author ning papel. "Ding tau maralas isipan da ing ECM metung yang inert protective outer layer na magprotekta kareng microorganisms. Pero malyari ya namang magsilbing conduit para kareng sustansya ampo enzymes kilub ampo kilwal da reng microbial cells."
Ing coating atin yang miyayaliwang obra: ing kayang stickiness mangabaldugan a deng indibidwal a microorganisms malyari lang mag clump para gawang colonies o “biofilms”, at nung sapat la reng microorganisms a gagawan da iti, malyari lang mag-clog kareng pipe o makakontamina kareng medical equipment.
Pero ing shell dapat ya namang maging permeable: dakal a microorganisms ing magsecrete miyayaliwang enzymes ampo aliwang metabolites kapamilatan ning ECM, papunta keng materyal a buri dang kanan o infect (antimo ing bulok a dutung o vertebrate tissue), at kaybat, nung ayari da na reng enzymes ing karelang obra, ing obra ning digestion – ibalik da la reng sustansya kapamilatan ning ECM.
Buri ng sabyan niti na ing ECM ali yamu metung a inert protective layer; Ing tutu na niti, antimo ing pepakit nang Goodell ampo reng kayabe na, deng microorganisms balamu atin lang abilidad a kontrolan ing viscosity ning karelang ECM at uli na niti ing kayang permeability. Makananu da gagawan ita?
Kareng fungi, balamu oxalic acid ing secretion, metung yang karaniwan a organic acid a natural a mayayakit kareng dakal a tanaman, at, antimo ing adiskubri nang Goodell ampo reng kayabe na, dakal lang microorganisms deng gagamitan da ing oxalic acid a papalwal da ba lang mitali kareng external layers da reng carbohydrates. gagawang malagkit a sangkap. , jelly-like ECM.
Pero inyang linawe lang masalese ning grupu, adiskubri da na ing oxalic acid e mu kabud sinaup king pamaglalang ECM, nune “me-regulate” ya naman: nung dakal la reng oxalic acid a idagdag da reng microbes king carbohydrate-acid mixture, mas maging viscous ya ing ECM. nung mas maging viscous ya ing ECM, mas babawal nala deng mangaragul a molecule para lungub o lumual keng microbe, kabang deng mangalating molecule manatili lang malayang lungub keng microbe ibat keng kapaligiran ampo vice versa.
Ing tuklas a ini sasalangsang ya keng tradisyunal a pamanintindi ning siyentipiku nung makananu la reng miyayaliwang uri da reng compound a papalwal da reng fungi ampo bacteria ibat kareng microorganisms a reni papunta keng kapaligiran. I Goodell ampo reng kayabe na sinabi da na keng mapilan a kasu deng microorganisms kailangan lang magdependi keng secretion da reng mangalating molecule para ataki ing matrix o tissue nung nukarin ya magdependi ing microorganism para mabye o maging infected. Ing buri nang sabyan niti, ing pamag-secrete da reng malating molecule malyari ya namang mika maragul a papil keng pathogenesis nung deng mangaragul a enzyme e la malyaring dumalan keng microbial extracellular matrix.
"Atin yang libutad," sinabi nang Goodell, "nung nukarin deng microorganisms malyari dong kontrolan ing acidity levels para maka-adapt la keng metung a partikular a kapaligiran, panatilyan da la reng mapilan kareng mangaragul a molecule, antimo reng enzymes, kabang paburen do reng mangalating molecule na dumalan la keng ECM. "Ing pamag-module keng ECM gamit ing oxalic acid malyari yang maging paralan para kareng microorganisms para protektan da ing karelang sarili kareng antibiotics, ampo antibiotics uling dakal kareng panulu a reni atin lang maragul a molecule. Iti ing abilidad ning pamag-customize na malyaring maging susi para alampasan ing metung kareng maragul a sagabal keng antimicrobial therapy, uling ing pamagmanipula keng ECM para maging mas permeable malyari yang magpasanting keng epektibidad da reng antibiotics ampo antimicrobials.

"Nung akontrol tamu ing biosynthesis ampo ing pamaglual da reng malating acid antimo ing oxalate kareng mapilan a microbes, kanita agyu tamung kontrolan nung nanu ing lulub kareng microbes, a malyaring magpaintulut kekatamu na mas masanting ing pamanulu kareng dakal a sakit a microbial," sinabi nang Goodell.
Inyang Disyembri 2022, ing microbiologist a i Yasu Morita tinggap ne ing grant ibat keng National Institutes of Health para suportan ing pamanyaliksik a buri nang gawang bayu, mas epektibung panulu para keng tuberculosis.

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